Integrating conventional DNA/RNA analysis methods into a microfluidic system can lead to exceedingly large, costly, and power-hungry systems. Instead, combine various DNA/RNA analysis methods on a single chip. Using simple microfluidic handling features, you can accurately drive and move fluids while minimizing device footprint, power consumption, complexity, cross-contamination, and equipment cost. For example, a closed on-chip valve and pump system drives and mixes reagents in a thermal chamber and uses a Peltier unit to apply thermal cycles. DNA purification is easily achieved with on-chip magnets isolating magnetic beads.